The Centers for Disease Control and Prevention (CDC) has released its latest situation update on mpox, highlighting continued global transmission while maintaining that the overall public risk in the United States remains low.
According to the CDC, mpox—formerly known as monkeypox—continues to circulate in multiple regions worldwide, particularly in parts of Central and Eastern Africa. Health officials report that outbreaks linked to Clade I, a more severe strain of the virus, are ongoing, contributing to tens of thousands of reported cases globally.
While the disease has historically been concentrated in endemic regions, recent data indicates that mpox has spread beyond Africa, with cases identified in parts of Europe and other regions. The CDC notes that international travel and close contact remain key factors driving transmission across borders.
In the United States, however, the situation remains relatively controlled. Since late 2024, only a small number of Clade I cases have been identified, most of which are associated with individuals who recently traveled internationally or had contact with travelers. Public health officials emphasize that the current risk to the general population is low.
The report also highlights the continued presence of Clade II, the strain responsible for the 2022 global outbreak. While still circulating, its spread has significantly slowed compared to earlier waves.
Mpox primarily spreads through close, prolonged contact, including skin-to-skin interaction, intimate contact, and exposure within households. In some regions, particularly where the virus is endemic, transmission from infected animals to humans can also occur.
Encouragingly, newer variants such as Clade Ib may be associated with lower fatality rates, although health authorities continue to monitor their behavior closely.
Vaccination remains a critical tool in preventing the spread of mpox, especially among high-risk groups. The CDC and international health partners are continuing surveillance efforts and response strategies to contain outbreaks and limit further transmission.
As global health agencies track developments, the CDC stresses the importance of awareness, early detection, and preventive measures to reduce the impact of mpox worldwide.